产品介绍 目录号
Serial | TCHu 36 | 标识符
Identifier | CSTR:19375.09.3101HUMTCHu36 | 描述
Description | MDA-MB-435S是一种纺锤形的细胞，1976年由其亲本(435)中筛选得到。435是从31岁的转移性乳腺导管腺癌女性患者胸水中分离得到。 当用荧光染料对微管蛋白进行染色时亲本细胞显现散布特征(II型)。 最近通过cDNA阵列研究表明，亲本(MDA-MB-435)可归入黑素瘤起源。
在本库通过支原体检测。
在本库通过STR检测。 | 动物种别
Organism | 人 | 性别
Gender | 女 | 组织来源
Tissue and Cell Type | 黑素细胞，黑素瘤以前认为是乳腺; 乳房; 导管; 导管癌; 胸腺渗出液 | 形态
Morphology | 纺锤形 | 培养基和添加剂
Complete Growth Medium and Culture Conditions | L-15培养基(GIBCO,货号41300039)和0.01mg/ml胰岛素，90%；优质胎牛血清，10%。
气相：空气，100%。
温度：37摄氏度。 | 供应限制
Permits and Restrictions | A。仅供研究之用。 | | REFERENCE | Brinkley BR , et al. Variations in cell form and cytoskeleton in human breast carcinoma cells in vitro. Cancer Res. 40: 3118-3129, 1980. PubMed: 7000337Siciliano MJ , et al. Mutually exclusive genetic signatures of human breast tumor cell lines with a common chromosomal marker. Cancer Res. 39: 919-922, 1979. PubMed: 427779Cailleau R , et al. Long-term human breast carcinoma cell lines of metastatic origin: preliminary characterization. In Vitro 14: 911-915, 1978. PubMed: 730202Sheng S , et al. Maspin acts at the cell membrane to inhibit invasion and motility of mammary and prostatic cancer cells. Proc. Natl. Acad. Sci. USA 93: 11669-11674, 1996. PubMed: 8876194Zhu X , et al. Cell cycle-dependent modulation of telomerase activity in tumor cells. Proc. Natl. Acad. Sci. USA 93: 6091-6095, 1996. PubMed: 8650224Ross DT , et al. Systematic variation in gene expression patterns in human cancer cell lines. Nature Genetics 24: 227-235, 2000. PubMed: 10700174Ellison G , et al. Further evidence to support the melanocytic origin of MDA-MB-435. Mol. Pathol. 55: 294-299, 2002. PubMed: 12354931 |
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